Pregnancy presents unique issues relevant to personalized therapeutics. Physiologic changes in pregnancy lead to increased volume of distribution, an extra compartment (the baby), and changes in drug metabolizing and transporting capabilities. Additionally, about 3 in 4 pregnant women are given a prescription for a non-vitamin medication during pregnancy. All of these factors make the study of drug therapy in pregnancy an important part of therapeutic studies.
Here at IUSM, through the Signature Center PREGMED- The Indiana University Center for Pharmacogenetics and Therapeutics Research in Maternal and Child Health, our team of researchers is performing cutting-edge research on pharmacogenomics and individualized therapy in pregnancy, focusing on conditions such as preterm labor, nausea and vomiting in pregnancy, depression in pregnancy, and diabetes in pregnancy. Uniquely merging interests in obstetrics, neonatology, and clinical pharmacology, this unique center is leading and participating in several federally funded studies to make drug therapy more individualized in pregnancy. In this way, PREGMED is helping to make possible the goal of happy moms and happy babies through personalized medicine.